Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis

Tularemia is a deadly, febrile disease caused by infection by the Gram-negative bacterium, Francisella tularensis. Members of the ubiquitous serine hydrolase protein family are among current targets to treat diverse bacterial infections. Herein we present a structural and functional study of a novel...

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Bibliografiske detaljer
Main Authors: Filippova, Ekaterina V., Weston, Leigh A., Kuhn, Misty L., Geissler, Brett, Gehring, Alexandra M., Armoush, Nicola, Adkins, Chinessa T., Minasov, George, Dubrovska, Ievgeniia, Shuvalova, Ludmilla, Winsor, James R., Lavis, Luke D., Satchell, Karla J. F., Becker, Daniel P., Anderson, Wayne F., Johnson, R. Jeremy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624434/
https://ncbi.nlm.nih.gov/pubmed/23430251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446625
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