Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis

Tularemia is a deadly, febrile disease caused by infection by the Gram-negative bacterium, Francisella tularensis. Members of the ubiquitous serine hydrolase protein family are among current targets to treat diverse bacterial infections. Herein we present a structural and functional study of a novel...

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Detalhes bibliográficos
Main Authors: Filippova, Ekaterina V., Weston, Leigh A., Kuhn, Misty L., Geissler, Brett, Gehring, Alexandra M., Armoush, Nicola, Adkins, Chinessa T., Minasov, George, Dubrovska, Ievgeniia, Shuvalova, Ludmilla, Winsor, James R., Lavis, Luke D., Satchell, Karla J. F., Becker, Daniel P., Anderson, Wayne F., Johnson, R. Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624434/
https://ncbi.nlm.nih.gov/pubmed/23430251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446625
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