Transcomplementation by a Truncation Mutant of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Enhances ΔF508 Processing through a Biomolecular Interaction

We previously showed that a truncation mutant of CFTR missing the first four transmembrane segments of TMD1, Δ264 CFTR, binds to key elements in the ER quality control mechanism to increase the amounts of the mature C band of both wt and ΔF508 CFTR through transcomplementation. Here, we created a ne...

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Detalles Bibliográficos
Autores principales: Cebotaru, Liudmila, Woodward, Owen, Cebotaru, Valeriu, Guggino, William B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624432/
https://ncbi.nlm.nih.gov/pubmed/23463513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.420489
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