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The Human Papillomavirus Type 8 E6 Protein Interferes with NOTCH Activation during Keratinocyte Differentiation

Cutaneous β-human papillomavirus (β-HPV) E6 proteins inhibit NOTCH signaling by associating with the transcriptional coactivator MAML1. NOTCH has tumor suppressor activities in epithelial cells and is activated during keratinocyte differentiation. Here we report that HPV type 8 (HPV8) E6 subverts NO...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Meyers, Jordan M., Spangle, Jennifer M., Munger, Karl
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624394/
https://ncbi.nlm.nih.gov/pubmed/23365452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02527-12
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