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The Human Papillomavirus Type 8 E6 Protein Interferes with NOTCH Activation during Keratinocyte Differentiation

Cutaneous β-human papillomavirus (β-HPV) E6 proteins inhibit NOTCH signaling by associating with the transcriptional coactivator MAML1. NOTCH has tumor suppressor activities in epithelial cells and is activated during keratinocyte differentiation. Here we report that HPV type 8 (HPV8) E6 subverts NO...

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Autores principales: Meyers, Jordan M., Spangle, Jennifer M., Munger, Karl
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624394/
https://ncbi.nlm.nih.gov/pubmed/23365452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02527-12
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