Identification of Critical Residues in the Hemagglutinin and Neuraminidase of Influenza Virus H1N1pdm for Vaccine Virus Replication in Embryonated Chicken Eggs

In 2009, we successfully produced a high-yield live attenuated H1N1pdm A/California/7/2009 vaccine (CA/09 LAIV) by substitution of three residues (K119E, A186D, and D222G) in the hemagglutinin (HA) protein. Since then, we have generated and evaluated additional H1N1pdm vaccine candidates from viruse...

Full description

Saved in:
Bibliographic Details
Main Authors: Wang, Weijia, Lu, Janine, Cotter, Christopher R., Wen, Katie, Jin, Hong, Chen, Zhongying
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624345/
https://ncbi.nlm.nih.gov/pubmed/23408613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03271-12
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items