Maribavir Inhibits Epstein-Barr Virus Transcription through the EBV Protein Kinase

Maribavir (MBV) inhibits Epstein-Barr virus (EBV) replication and the enzymatic activity of the viral protein kinase BGLF4. MBV also inhibits expression of multiple EBV transcripts during EBV lytic infection. Here we demonstrate, with the use of a BGLF4 knockout virus, that effects of MBV on transcr...

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Hlavní autoři: Whitehurst, Christopher B., Sanders, Marcia K., Law, Mankit, Wang, Fu-Zhang, Xiong, Jie, Dittmer, Dirk P., Pagano, Joseph S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624302/
https://ncbi.nlm.nih.gov/pubmed/23449792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03505-12
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