Airway Delivery of an Adenovirus-Based Ebola Virus Vaccine Bypasses Existing Immunity to Homologous Adenovirus in Nonhuman Primates

Anti-adenovirus serotype 5 antibodies are capable of neutralizing adenovirus serotype 5-based vaccines. In mice and guinea pigs, intranasal delivery of adenovirus serotype 5-based vaccine bypasses induced adenovirus serotype 5 preexisting immunity, resulting in protection against species-adapted Ebo...

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Autores principales: Richardson, Jason S., Pillet, Stéphane, Bello, Alexander J., Kobinger, Gary P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624216/
https://ncbi.nlm.nih.gov/pubmed/23302894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02864-12
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