Activity and Mechanism of Action of HDVD, a Novel Pyrimidine Nucleoside Derivative with High Levels of Selectivity and Potency against Gammaherpesviruses

A novel nucleoside analogue, 1-[(2S,4S-2-(hydroxymethyl)-1,3-dioxolan-4-yl]5-vinylpyrimidine-2,4(1H,3H)-dione, or HDVD, was evaluated against a wide variety of herpesviruses and was found to be a highly selective inhibitor of replication of the gammaherpesviruses Kaposi's sarcoma-associated her...

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Main Authors: Coen, N., Singh, U., Vuyyuru, V., Van den Oord, J. J., Balzarini, J., Duraffour, S., Snoeck, R., Cheng, Y. C., Chu, C. K., Andrei, G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624198/
https://ncbi.nlm.nih.gov/pubmed/23345517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03338-12
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