Homopiperazine Derivatives as a Novel Class of Proteasome Inhibitors with a Unique Mode of Proteasome Binding

The proteasome is a proteolytic machinery that executes the degradation of polyubiquitinated proteins to maintain cellular homeostasis. Proteasome inhibition is a unique and effective way to kill cancer cells because they are sensitive to proteotoxic stress. Indeed, the proteasome inhibitor bortezom...

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Main Authors: Kikuchi, Jiro, Shibayama, Naoya, Yamada, Satoshi, Wada, Taeko, Nobuyoshi, Masaharu, Izumi, Tohru, Akutsu, Miyuki, Kano, Yasuhiko, Sugiyama, Kanako, Ohki, Mio, Park, Sam-Yong, Furukawa, Yusuke
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623906/
https://ncbi.nlm.nih.gov/pubmed/23593271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060649
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