Purine Analog-Like Properties of Bendamustine Underlie Rapid Activation of DNA Damage Response and Synergistic Effects with Pyrimidine Analogues in Lymphoid Malignancies

Bendamustine has shown considerable clinical activity against indolent lymphoid malignancies as a single agent or in combination with rituximab, but combination with additional anti-cancer drugs may be required for refractory and/or relapsed cases as well as other intractable tumors. In this study,...

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Autors principals: Hiraoka, Nobuya, Kikuchi, Jiro, Yamauchi, Takahiro, Koyama, Daisuke, Wada, Taeko, Uesawa, Mitsuyo, Akutsu, Miyuki, Mori, Shigehisa, Nakamura, Yuichi, Ueda, Takanori, Kano, Yasuhiko, Furukawa, Yusuke
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953125/
https://ncbi.nlm.nih.gov/pubmed/24626203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090675
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