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Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8
Relatively little is known about the regulatory mechanisms of the Drosha/DGCR8 complex, which processes miRNAs at the initial step of biogenesis. We found that histone deacetylase 1 (HDAC1) increases the expression levels of mature miRNAs despite repressing the transcription of host genes. HDAC1 is...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3271337/ https://ncbi.nlm.nih.gov/pubmed/22222205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.247 |
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