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Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8

Relatively little is known about the regulatory mechanisms of the Drosha/DGCR8 complex, which processes miRNAs at the initial step of biogenesis. We found that histone deacetylase 1 (HDAC1) increases the expression levels of mature miRNAs despite repressing the transcription of host genes. HDAC1 is...

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書目詳細資料
Main Authors: Wada, Taeko, Kikuchi, Jiro, Furukawa, Yusuke
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271337/
https://ncbi.nlm.nih.gov/pubmed/22222205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.247
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