Development of a robust flow cytometry-based pharmacodynamic assay to detect phospho-protein signals for phosphatidylinositol 3-kinase inhibitors in multiple myeloma

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in multiple myeloma (MM), a blood cancer associated with uncontrolled proliferation of bone marrow plasma cells. This study aimed to develop a robust clinical pharmacodynamic (PD) assay to measure the on-target PD e...

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Detalhes bibliográficos
Principais autores: Li, Congfen, Takahashi, Chikara, Zhang, Liangxuan, Huseni, Mahrukh, Stankovich, Basha, Mashhedi, Haider, Lee, Joanna, French, Dorothy, Anderson, Jeff Eastham, Kim, Doris, Howell, Kathy, Brauer, Matthew J, Kowanetz, Marcin, Yan, Yibing, Humke, Eric, Ebens, Allen, Hampton, Garret, Lackner, Mark R, Hegde, Priti, Jia, Shidong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623880/
https://ncbi.nlm.nih.gov/pubmed/23522020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-76
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