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Evaluation of Recombinant 2009 Pandemic Influenza A (H1N1) Viruses Harboring Zanamivir Resistance Mutations in Mice and Ferrets

Recombinant influenza A(H1N1)pdm09 wild-type (WT) and zanamivir-resistant E119G and Q136K neuraminidase mutants were generated to determine their enzymatic and replicative properties in vitro, as well as their infectivity and transmissibility in mice and ferrets. Viral titers of recombinant E119G an...

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Bibliografiske detaljer
Main Authors: Pizzorno, Andrés, Abed, Yacine, Rhéaume, Chantal, Bouhy, Xavier, Boivin, Guy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623354/
https://ncbi.nlm.nih.gov/pubmed/23357777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02269-12
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