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Evaluation of Recombinant 2009 Pandemic Influenza A (H1N1) Viruses Harboring Zanamivir Resistance Mutations in Mice and Ferrets

Recombinant influenza A(H1N1)pdm09 wild-type (WT) and zanamivir-resistant E119G and Q136K neuraminidase mutants were generated to determine their enzymatic and replicative properties in vitro, as well as their infectivity and transmissibility in mice and ferrets. Viral titers of recombinant E119G an...

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Autores principales: Pizzorno, Andrés, Abed, Yacine, Rhéaume, Chantal, Bouhy, Xavier, Boivin, Guy
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623354/
https://ncbi.nlm.nih.gov/pubmed/23357777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02269-12
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