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Impact of Mutations at Residue I223 of the Neuraminidase Protein on the Resistance Profile, Replication Level, and Virulence of the 2009 Pandemic Influenza Virus

Amino acid substitutions at residue I223 of the neuraminidase (NA) protein have been identified in 2009 pandemic influenza (pH1N1) variants with altered susceptibilities to NA inhibitors (NAIs). We used reverse genetics and site-directed mutagenesis to generate the recombinant A/Québec/144147/09 pH1...

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Detalhes bibliográficos
Main Authors: Pizzorno, Andrés, Abed, Yacine, Bouhy, Xavier, Beaulieu, Édith, Mallett, Corey, Russell, Rupert, Boivin, Guy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294894/
https://ncbi.nlm.nih.gov/pubmed/22203589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05994-11
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