Chimeric Beta-Defensin Analogs, Including the Novel 3NI Analog, Display Salt-Resistant Antimicrobial Activity and Lack Toxicity in Human Epithelial Cell Lines

Human beta-defensins (hBDs) are crucial peptides for the innate immune response and are thus prime candidates as therapeutic agents directed against infective diseases. Based on the properties of wild-type hBD1 and hBD3 and of previously synthesized analogs (1C, 3I, and 3N), we have designed a new a...

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Autori principali: Scudiero, Olga, Galdiero, Stefania, Nigro, Ersilia, Del Vecchio, Luigi, Di Noto, Rosa, Cantisani, Marco, Colavita, Irene, Galdiero, Massimiliano, Cassiman, Jean-Jacques, Daniele, Aurora, Pedone, Carlo, Salvatore, Francesco
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623310/
https://ncbi.nlm.nih.gov/pubmed/23357761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00934-12
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