Novel Synthetic, Salt-Resistant Analogs of Human Beta-Defensins 1 and 3 Endowed with Enhanced Antimicrobial Activity

Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high salt levels. We have designed and synthesized seven novel hBD analogs, constituted by different domains of hBD1 (which i...

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Hauptverfasser: Scudiero, Olga, Galdiero, Stefania, Cantisani, Marco, Di Noto, Rosa, Vitiello, Mariateresa, Galdiero, Massimiliano, Naclerio, Gino, Cassiman, Jean-Jacques, Pedone, Carlo, Castaldo, Giuseppe, Salvatore, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876405/
https://ncbi.nlm.nih.gov/pubmed/20308372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01550-09
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