Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool

We have designed a cyclic 17-amino acid β-defensin analog featuring a single disulfide bond. This analog, designated “AMC” (ie, antimicrobial cyclic peptide), combines the internal hydrophobic domain of hBD1 and the C-terminal charged region of hBD3. The novel peptide was synthesized and characteriz...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Nanomedicine
Prif Awduron: Scudiero, Olga, Nigro, Ersilia, Cantisani, Marco, Colavita, Irene, Leone, Marilisa, Mercurio, Flavia Anna, Galdiero, Massimiliano, Pessi, Antonello, Daniele, Aurora, Salvatore, Francesco, Galdiero, Stefania
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Dove Medical Press 2015
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610797/
https://ncbi.nlm.nih.gov/pubmed/26508857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S89610
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg