Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool

We have designed a cyclic 17-amino acid β-defensin analog featuring a single disulfide bond. This analog, designated “AMC” (ie, antimicrobial cyclic peptide), combines the internal hydrophobic domain of hBD1 and the C-terminal charged region of hBD3. The novel peptide was synthesized and characteriz...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Scudiero, Olga, Nigro, Ersilia, Cantisani, Marco, Colavita, Irene, Leone, Marilisa, Mercurio, Flavia Anna, Galdiero, Massimiliano, Pessi, Antonello, Daniele, Aurora, Salvatore, Francesco, Galdiero, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610797/
https://ncbi.nlm.nih.gov/pubmed/26508857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S89610
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