Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse

Genetic polymorphism in MECP2/IRAK1 on chromosome Xq28 is a confirmed and replicated susceptibility locus for lupus. High linkage disequilibrium in this locus suggests that both MECP2 and IRAK1 are candidate genes for the disease. DNA methylation changes in lupus T cells play a central role in the p...

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Huvudupphovsmän: Koelsch, Kristi A., Webb, Ryan, Jeffries, Matlock, Dozmorov, Mikhail G., Frank, Mark Barton, Guthridge, Joel M., James, Judith A., Wren, Jonathan D., Sawalha, Amr H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622940/
https://ncbi.nlm.nih.gov/pubmed/23428850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2012.12.012
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