Variants within MECP2, a key transcriptional regulator, are associated with increased susceptibility to lupus and differential gene expression in lupus patients

OBJECTIVE: Both genetic and epigenetic factors play an important role in the pathogenesis of lupus. Herein, we study methyl-CpG-binding protein 2 (MECP2) polymorphism in a large cohort of lupus patients and controls, and determine functional consequences of the lupus-associated MECP2 haplotype. METH...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Webb, Ryan, Wren, Jonathan D, Jeffries, Matlock, Kelly, Jennifer A, Kaufman, Kenneth M, Tang, Yuhong, Frank, Mark Barton, Merrill, Joan, Alarcón-Riquelme, Marta E, James, Judith A, Vyse, Timothy J, Moser, Kathy L, Gilkeson, Gary S, Harley, John B, Sawalha, Amr H
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2009
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734382/
https://ncbi.nlm.nih.gov/pubmed/19333917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24360
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