Observation of an Unusual Electronically Distorted Semiquinone Radical of PCB Metabolites in the Active Site of Prostaglandin H Synthase-2

The activation of the metabolites of airborne polychlorinated biphenyls (PCBs) into highly reactive radicals is of fundamental importance. We found that human recombinant prostaglandin H synthase-2 (hPGHS-2) biotransforms dihydroxy-PCBs, such as 4-chlorobiphenyl-2′,5′-hydroquinone (4-CB-2′,5′H(2)Q),...

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Hlavní autoři: Wangpradit, Orarat, Moman, Edelmiro, Nolan, Kevin B., Buettner, Garry R., Robertson, Larry W., Luthe, Gregor
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622869/
https://ncbi.nlm.nih.gov/pubmed/20843536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chemosphere.2010.08.041
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