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Tuning the molecular giant titin through phosphorylation-role in health and disease
Titin is a giant multi-functional filament that spans the half sarcomere. Titin’s extensible I-band region functions as a molecular spring that provides passive stiffness to cardiac myocytes. Elevated diastolic stiffness is found in a large fraction of heart failure patients and thus understanding t...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3622841/ https://ncbi.nlm.nih.gov/pubmed/23295080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcm.2012.10.005 |
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