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Fragments of the Bacterial Toxin Microcin B17 as Gyrase Poisons

Fluoroquinolones are very important drugs in the clinical antibacterial arsenal; their success is principally due to their mode of action: the stabilisation of a gyrase-DNA intermediate (the cleavage complex), which triggers a chain of events leading to cell death. Microcin B17 (MccB17) is a modifie...

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Autors principals: Collin, Frédéric, Thompson, Robert E., Jolliffe, Katrina A., Payne, Richard J., Maxwell, Anthony
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622597/
https://ncbi.nlm.nih.gov/pubmed/23593482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061459
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