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Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation

Human hemoglobins, the oxygen carriers in the blood, are composed by two α-like and two β-like globin monomers. The β-globin gene cluster located at 11p15.5 comprises one pseudogene and five genes whose expression undergoes two critical switches: the embryonic-to-fetal and fetal-to-adult transition....

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Autori principali: Moleirinho, Ana, Seixas, Susana, Lopes, Alexandra M., Bento, Celeste, Prata, Maria J., Amorim, António
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622298/
https://ncbi.nlm.nih.gov/pubmed/23431002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evt029
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