Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain

Pregabalin is effective in treating many neuropathic pain conditions. However, the mechanisms of its analgesic effects remain poorly understood. The aim of the present study was to determine whether pregabalin suppresses facial mechanical hypersensitivity and evoked glutamate release in the medullar...

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Hauptverfasser: Kumar, Naresh, Cherkas, Pavel S., Varathan, Vidya, Miyamoto, Makiko, Chiang, C.Y., Dostrovsky, Jonathan O., Sessle, Barry J., Coderre, Terence J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622144/
https://ncbi.nlm.nih.gov/pubmed/23454190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2013.02.022
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