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Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain

Pregabalin is effective in treating many neuropathic pain conditions. However, the mechanisms of its analgesic effects remain poorly understood. The aim of the present study was to determine whether pregabalin suppresses facial mechanical hypersensitivity and evoked glutamate release in the medullar...

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Detalhes bibliográficos
Main Authors: Kumar, Naresh, Cherkas, Pavel S., Varathan, Vidya, Miyamoto, Makiko, Chiang, C.Y., Dostrovsky, Jonathan O., Sessle, Barry J., Coderre, Terence J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622144/
https://ncbi.nlm.nih.gov/pubmed/23454190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2013.02.022
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