A synthetic intron in a naturally intronless yeast pre-tRNA is spliced efficiently in vivo.

Saccharomyces cerevisiae glutamine tRNA(CAG) is encoded by an intronless, single-copy gene, SUP60. We have imposed a requirement for splicing in the biosynthesis of this tRNA by inserting a synthetic intron in the SUP60 gene. Genetic analysis demonstrated that the interrupted gene produces a functio...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Winey, M, Edelman, I, Culbertson, M R
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362177/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2648132/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.1.329
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