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Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling

BACKGROUND: The few currently available drugs for treatment of African trypanosomiasis are outdated and show problems with toxicity and resistance. Hence, there is an urgent need for the discovery and development of new anti-trypanosomal agents. FINDINGS: In this study, the ionophorous antibiotic sa...

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Autors principals: Steverding, Dietmar, Sexton, Darren W
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621689/
https://ncbi.nlm.nih.gov/pubmed/23517602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-3305-6-78
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