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Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling

BACKGROUND: The few currently available drugs for treatment of African trypanosomiasis are outdated and show problems with toxicity and resistance. Hence, there is an urgent need for the discovery and development of new anti-trypanosomal agents. FINDINGS: In this study, the ionophorous antibiotic sa...

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Detalhes bibliográficos
Main Authors: Steverding, Dietmar, Sexton, Darren W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621689/
https://ncbi.nlm.nih.gov/pubmed/23517602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-3305-6-78
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