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Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification

The core gene regulatory network (GRN) in embryonic stem cells (ESCs) integrates activities of the pro-self-renewal factors Oct4 (Pou5f1), Sox2 and Nanog with that of an inhibitor of self-renewal, Tcf7l1 (Tcf3). The inhibitor function of Tcf7l1 causes dependence on extracellular Wnt/β-catenin signal...

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書目詳細資料
Main Authors: Hoffman, Jackson A., Wu, Chun-I, Merrill, Bradley J.
格式: Artigo
語言:Inglês
出版: Company of Biologists 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621485/
https://ncbi.nlm.nih.gov/pubmed/23487311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.087387
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