Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation

BACKGROUND: FTY720 (fingolimod, Gilenya™) is a daily oral therapy for multiple sclerosis that readily accesses the central nervous system (CNS). FTY720 is a structural analog to the sphingolipid sphingosine-1-phosphate (S1P) and is a cognate ligand for the S1P G-protein coupled receptors (S1PR). Stu...

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Autores principales: Wu, Celina, Leong, Soo Y, Moore, Craig S, Cui, Qiao Ling, Gris, Pavel, Bernier, Louis-Philippe, Johnson, Trina A, Séguéla, Philippe, Kennedy, Timothy E, Bar-Or, Amit, Antel, Jack P
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621211/
https://ncbi.nlm.nih.gov/pubmed/23509960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-41
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