Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor–induced lethal hepatitis

S-adenosyl-L-methionine (SAM) is synthesized by methionine adenosyltransferases (MATs). Ablation of the liver-specific MAT1A gene results in liver neoplasia and sensitivity to oxidant injury. Here we show that acidic sphingomyelinase (ASMase) mediates the downregulation of MAT1A by TNF-α. The levels...

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Bibliographic Details
Main Authors: Marí, Montserrat, Colell, Anna, Morales, Albert, Pañeda, Covadonga, Varela-Nieto, Isabel, García-Ruiz, Carmen, Fernández-Checa, José C.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC362116/
https://ncbi.nlm.nih.gov/pubmed/15067322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419852
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