Anti-tumor necrosis factor (V)NAR single domains reduce lethality and regulate underlying inflammatory response in a murine model of endotoxic shock

BACKGROUND: In sepsis, tumor necrosis factor (TNF) is the key factor triggering respiratory burst, tissue injury and disseminated coagulation. Anti-TNF strategies based on monoclonal antibodies or F(ab’)(2) fragments have been used in sepsis with contradictory results. Immunoglobulin new antigen rec...

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Main Authors: Bojalil, Rafael, Mata-González, María Teresa, Sánchez-Muñoz, Fausto, Yee, Yepci, Argueta, Iván, Bolaños, Lucía, Amezcua-Guerra, Luis Manuel, Camacho-Villegas, Tanya Amanda, Sánchez-Castrejón, Edna, García-Ubbelohde, Walter Jakob, Licea-Navarro, Alexei Fedorovish, Márquez-Velasco, Ricardo, Paniagua-Solís, Jorge Fernando
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621089/
https://ncbi.nlm.nih.gov/pubmed/23548047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-14-17
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