Warfarin Accelerates Ectopic Mineralization in Abcc6(−/−) Mice: Clinical Relevance to Pseudoxanthoma Elasticum

Pseudoxanthoma elasticum (PXE) is a multisystem ectopic mineralization disorder caused by mutations in the ABCC6 gene. Warfarin, a commonly used anticoagulant, is associated with increased mineralization of the arterial blood vessels and cardiac valves. We hypothesized that warfarin may accelerate e...

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Main Authors: Li, Qiaoli, Guo, Haitao, Chou, David W., Harrington, Dominic J., Schurgers, Leon J., Terry, Sharon F., Uitto, Jouni
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620423/
https://ncbi.nlm.nih.gov/pubmed/23415960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.12.037
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