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Identification of Aurora Kinase B and Wee1-Like Protein Kinase as Downstream Targets of (V600E)B-RAF in Melanoma
BRAF is the most mutated gene in melanoma, with approximately 50% of patients containing V600E mutant protein. (V600E)B-RAF can be targeted using pharmacological agents, but resistance develops in patients by activating other proteins in the signaling pathway. Identifying downstream members in this...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3620396/ https://ncbi.nlm.nih.gov/pubmed/23416158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.12.019 |
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