Identification of Aurora Kinase B and Wee1-Like Protein Kinase as Downstream Targets of (V600E)B-RAF in Melanoma

BRAF is the most mutated gene in melanoma, with approximately 50% of patients containing V600E mutant protein. (V600E)B-RAF can be targeted using pharmacological agents, but resistance develops in patients by activating other proteins in the signaling pathway. Identifying downstream members in this...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sharma, Arati, Madhunapantula, SubbaRao V., Gowda, Raghavendra, Berg, Arthur, Neves, Rogerio I., Robertson, Gavin P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Investigative Pathology 2013
Pynciau:
Regular Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620396/
https://ncbi.nlm.nih.gov/pubmed/23416158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.12.019
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