Identification of WEE1 as a target to make AKT inhibition more effective in melanoma

AKT3 is one of the major therapeutic targets in melanoma but clinically targeting AKT3 alone seems to be an ineffective therapeutic approach. To identify unique strategies to enhance the efficacy of targeting AKT3, a screen was undertaken where AKT3 was co-targeted with a panel of kinases important...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Biol Ther
Auteurs principaux: Kuzu, Omer F., Gowda, Raghavendra, Sharma, Arati, Noory, Mohammad A., Kardos, Gregory, Madhunapantula, SubbaRao V., Drabick, Joseph J., Robertson, Gavin P.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2017
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790369/
https://ncbi.nlm.nih.gov/pubmed/28853983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1360446
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