Identification of WEE1 as a target to make AKT inhibition more effective in melanoma

AKT3 is one of the major therapeutic targets in melanoma but clinically targeting AKT3 alone seems to be an ineffective therapeutic approach. To identify unique strategies to enhance the efficacy of targeting AKT3, a screen was undertaken where AKT3 was co-targeted with a panel of kinases important...

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Dettagli Bibliografici
Pubblicato in:Cancer Biol Ther
Autori principali: Kuzu, Omer F., Gowda, Raghavendra, Sharma, Arati, Noory, Mohammad A., Kardos, Gregory, Madhunapantula, SubbaRao V., Drabick, Joseph J., Robertson, Gavin P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790369/
https://ncbi.nlm.nih.gov/pubmed/28853983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1360446
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