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Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

4-1BB agonist antibody treatment induces a population of KLRG1(+) T cells that infiltrate melanoma tumors. We investigated the origin and function of these cells, as well as their place within established T cell paradigms. We find that these T cells, particularly the CD4 lineage, represent a novel p...

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Main Authors: Curran, Michael A., Geiger, Theresa L., Montalvo, Welby, Kim, Myoungjoo, Reiner, Steven L., Al-Shamkhani, Aymen, Sun, Joseph C., Allison, James P.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620352/
https://ncbi.nlm.nih.gov/pubmed/23547098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121190
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