Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

Fragile X syndrome (FXS) is the most common inherited form of autism and intellectual disability and is caused by the silencing of a single gene, fragile X mental retardation 1 (Fmr1). The Fmr1 KO mouse displays phenotypes similar to symptoms in the human condition—including hyperactivity, repetitiv...

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Hauptverfasser: Dolan, Bridget M., Duron, Sergio G., Campbell, David A., Vollrath, Benedikt, Rao, B. S. Shankaranarayana, Ko, Hui-Yeon, Lin, Gregory G., Govindarajan, Arvind, Choi, Se-Young, Tonegawa, Susumu
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619302/
https://ncbi.nlm.nih.gov/pubmed/23509247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219383110
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