Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice

Fragile X syndrome (FXS), the most commonly inherited form of mental retardation and autism, is caused by transcriptional silencing of the fragile X mental retardation 1 (FMR1) gene and consequent loss of the fragile X mental retardation protein. Despite growing evidence suggesting a role of specifi...

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Autores principales: Hayashi, Mansuo L., Rao, B. S. Shankaranarayana, Seo, Jin-Soo, Choi, Han-Saem, Dolan, Bridget M., Choi, Se-Young, Chattarji, Sumantra, Tonegawa, Susumu
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899186/
https://ncbi.nlm.nih.gov/pubmed/17592139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705003104
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