Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule

BACKGROUND: Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability and is also associated with autism spectrum disorders. Previous studies implicated BKCa channels in the neuropathogenesis of FXS, but the main question was whether pharmacological BKCa stimulation would...

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Detalhes bibliográficos
Publicado no:Orphanet J Rare Dis
Main Authors: Hébert, Betty, Pietropaolo, Susanna, Même, Sandra, Laudier, Béatrice, Laugeray, Anthony, Doisne, Nicolas, Quartier, Angélique, Lefeuvre, Sandrine, Got, Laurence, Cahard, Dominique, Laumonnier, Frédéric, Crusio, Wim E, Pichon, Jacques, Menuet, Arnaud, Perche, Olivier, Briault, Sylvain
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237919/
https://ncbi.nlm.nih.gov/pubmed/25079250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-014-0124-6
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