Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule

BACKGROUND: Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability and is also associated with autism spectrum disorders. Previous studies implicated BKCa channels in the neuropathogenesis of FXS, but the main question was whether pharmacological BKCa stimulation would...

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Dettagli Bibliografici
Pubblicato in:Orphanet J Rare Dis
Autori principali: Hébert, Betty, Pietropaolo, Susanna, Même, Sandra, Laudier, Béatrice, Laugeray, Anthony, Doisne, Nicolas, Quartier, Angélique, Lefeuvre, Sandrine, Got, Laurence, Cahard, Dominique, Laumonnier, Frédéric, Crusio, Wim E, Pichon, Jacques, Menuet, Arnaud, Perche, Olivier, Briault, Sylvain
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237919/
https://ncbi.nlm.nih.gov/pubmed/25079250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-014-0124-6
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