Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule

BACKGROUND: Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability and is also associated with autism spectrum disorders. Previous studies implicated BKCa channels in the neuropathogenesis of FXS, but the main question was whether pharmacological BKCa stimulation would...

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Bibliografiske detaljer
Udgivet i:Orphanet J Rare Dis
Main Authors: Hébert, Betty, Pietropaolo, Susanna, Même, Sandra, Laudier, Béatrice, Laugeray, Anthony, Doisne, Nicolas, Quartier, Angélique, Lefeuvre, Sandrine, Got, Laurence, Cahard, Dominique, Laumonnier, Frédéric, Crusio, Wim E, Pichon, Jacques, Menuet, Arnaud, Perche, Olivier, Briault, Sylvain
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237919/
https://ncbi.nlm.nih.gov/pubmed/25079250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-014-0124-6
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