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Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1α genes

Based on the rapid hydrolysis of acetyl salicylic acid (ASA, Aspirin) to salicylic acid (SA), the ability of SA to form dihydroxy benzoic acid (DBA), and the latter’s redox reactions to yield hydrogen peroxide (H(2)O(2)), we predicted that ASA may have the potential to induce Sirtuin1 (Sirt1) and it...

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Detalhes bibliográficos
Main Authors: Kamble, Pratibha, Selvarajan, Krithika, Narasimhulu, Chandrakala Aluganti, Nandave, Mukesh, Parthasarathy, Sampath
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619195/
https://ncbi.nlm.nih.gov/pubmed/23228932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2012.11.051
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