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Targeted Mutations of Bacillus anthracis Dihydrofolate Reductase Condense Complex Structure-Activity Relationships
Several antifolates, including trimethoprim (TMP) and a series of propargyl-linked analogs, bind dihydrofolate reductase from Bacillus anthracis (BaDHFR) with lower affinity than is typical in other bacterial species. To guide lead optimization for BaDHFR, we explored a new approach to determine str...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3618964/ https://ncbi.nlm.nih.gov/pubmed/20882962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100727t |
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