Synthesis and Characterization of DNA Minor Groove Binding Alkylating Agents

Derivatives of methyl 3-(1-methyl-5-(1-methyl-5-(propylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylamino)-3-oxopropane-1-sulfonate (1), a peptide-based DNA minor groove binding methylating agent, were synthesized and characterized. In all cases the N-terminus was appended with a O-methyl sulfo...

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Main Authors: Iyer, Prema, Srinivasan, Ajay, Singh, Sreelekha K., Mascara, Gerard P., Zayitova, Sevara, Sidone, Brian, Fouquerel, Elise, Svilar, David, Sobol, Robert W., Bobola, Michael S., Silber, John R., Gold, Barry
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618862/
https://ncbi.nlm.nih.gov/pubmed/23234400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300437x
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