Estimation of the haematological toxicity of minor groove alkylators using tests on human cord blood cells.

We evaluated the myelotoxicity and the anti-tumor potential of tallimustine, three of its analogues and carzelesin, with melphalan as reference substance. Tallimustine was tested by clonogenic assays on both human bone marrow (BM) and cord blood (hCB) cells, the other compounds on hCB only. The degr...

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Main Authors: Ghielmini, M., Bosshard, G., Capolongo, L., Geroni, M. C., Pesenti, E., Torri, V., D'Incalci, M., Cavalli, F., Sessa, C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group|1 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063413/
https://ncbi.nlm.nih.gov/pubmed/9062410
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