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α-Bromoacryloyl derivative of distamycin A (PNU 151807): a new non-covalent minor groove DNA binder with antineoplastic activity

PNU 151807 is a new synthetic α-bromoacryloyl derivative of distamycin A. In the present study we investigated the DNA interaction and the mechanism of action of this compound in parallel with the distamycin alkylating derivative, tallimustine. PNU 151807 possesses a good cytotoxic activity in in vi...

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Detalhes bibliográficos
Main Authors: Marchini, S, Cirò, M, Gallinari, F, Geroni, C, Cozzi, P, D'Incalci, M, Broggini, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363030/
https://ncbi.nlm.nih.gov/pubmed/10362106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690453
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