α-Bromoacryloyl derivative of distamycin A (PNU 151807): a new non-covalent minor groove DNA binder with antineoplastic activity

PNU 151807 is a new synthetic α-bromoacryloyl derivative of distamycin A. In the present study we investigated the DNA interaction and the mechanism of action of this compound in parallel with the distamycin alkylating derivative, tallimustine. PNU 151807 possesses a good cytotoxic activity in in vi...

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Detaylı Bibliyografya
Asıl Yazarlar: Marchini, S, Cirò, M, Gallinari, F, Geroni, C, Cozzi, P, D'Incalci, M, Broggini, M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 1999
Konular:
Regular Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363030/
https://ncbi.nlm.nih.gov/pubmed/10362106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690453
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