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Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility

PURPOSE: Epilepsy is a complex disease characterized by a predisposition toward seizures. There are numerous barriers to the successful treatment of epilepsy. For instance, current anti-epileptic drugs have adverse side effects and variable efficacies. Further, the pathophysiological basis of epilep...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Distler, Margaret G., Gorfinkle, Naomi, Papale, Ligia A., Wuenschell, Gerald E., Termini, John, Escayg, Andrew, Winawer, Melodie R., Palmer, Abraham A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618549/
https://ncbi.nlm.nih.gov/pubmed/23409935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12121
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