Glyoxalase 1 increases anxiety by reducing GABA(A) receptor agonist methylglyoxal

Glyoxalase 1 (Glo1) expression has previously been associated with anxiety in mice; however, its role in anxiety is controversial, and the underlying mechanism is unknown. Here, we demonstrate that GLO1 increases anxiety by reducing levels of methylglyoxal (MG), a GABA(A) receptor agonist. Mice over...

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Hlavní autoři: Distler, Margaret G., Plant, Leigh D., Sokoloff, Greta, Hawk, Andrew J., Aneas, Ivy, Wuenschell, Gerald E., Termini, John, Meredith, Stephen C., Nobrega, Marcelo A., Palmer, Abraham A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366407/
https://ncbi.nlm.nih.gov/pubmed/22585572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61319
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