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Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.

The B-chain homodimer of platelet-derived growth factor (PDGF) is only very inefficiently secreted and remains largely associated with the producer cell; in contrast, the dimer of the short, and most common, splice variant of the A-chain is secreted. To identify the structural background to the diff...

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Détails bibliographiques
Publié dans:Cell Regul
Auteurs principaux: Ostman, A, Andersson, M, Betsholtz, C, Westermark, B, Heldin, C H
Format: Artigo
Langue:Inglês
Publié: American Society for Cell Biology 1991
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361840/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1782212/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.2.7.503
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