Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant.

A non-receptor-binding mutant of the platelet-derived growth factor (PDGF) A chain, PDGF-0, was generated by exchanging 7 amino acids in the sequence. The mutant chains formed dimers that were similar to wild-type PDGF-AA with regard to stability and rate of processing to the mature 30-kDa secreted...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Vassbotn, F S, Andersson, M, Westermark, B, Heldin, C H, Ostman, A
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359956/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8321214/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.7.4066
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